Fortunately, it does not feel like a 3DS, instead it is a pleasure to hold, a triumph of ergonomic design. By removing the hinges and creating a flat surface there is no longer a top-heaviness to the system. The lack of a large separation in the middle of the 2DS has also enabled Nintendo to move the buttons and analog stick to the center of the device, which not only helps in terms of comfort, but also in balancing the system in your hands.
The face buttons, while seemingly in a similar position as on the 3DS, are actually higher and therefore more comfortable to use since you no longer have to bend your thumbs as much to use them. The analog stick lines up with the face buttons which results in the weight of the 2DS being equally balanced.
The shoulder buttons are even more of a coup, placed perfectly on the top, so even if you are not using them it helps in holding the 2DS in a stable position.